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The original Ketogenic Therapy, known as the classic Ketogenic Diet, or classic Keto for short, was designed in by Dr. Russell Wilder at the Mayo Clinic for the treatment of epilepsy. Classic Keto carries a ratio, which means that there are four parts fat for every one part protein and carb. The main difference between the five types of Ketogenic Diets is this macronutrient ratio. All Ketogenic Diets are high in fat, adequate in protein and low in carbohydrates. This combination changes the way energy is used in the body, converting fat into fatty acids and ketones in the liver.
Scientists at the Gladstone Institute, a San Francisco—based research center, found that powerful antioxidant and anti-inflammatory genes are activated by beta-hydroxybutyrate, a ketone body produced when you limit calories or carbs. The classical and modified MCT ketogenic diets are equally effective and differences in tolerability are not statistically significant. Ferriss told the story of a friend with testicular cancer who would fast for three days, entering into ketosis, before chemotherapy. This method of ketogenic diet delivery has since been reported effective in over 40 patients in a dozen separate medical publications.